264. The Hunger Genes - MC4R, ANKK1, Satiety, and Fasting
The FIT Collective Genetic Insights Series – Episode 2
Unlock the Secrets of Your Hunger Genetics and Eating Habits
In this fascinating episode, Dr. Ali Novitsky, Obesity Medicine Expert and Fitness Guru, explores the powerful role genetics play in shaping our appetite, eating behaviors, and how we experience fullness (satiety). Drawing from science and personal experience, she breaks down how certain genes influence appetite, body composition, and emotional eating — and how understanding your genetic blueprint can empower you to make personalized, sustainable health choices.
👩👧 Personal Touches & Real-Life Insights
Dr. Novitsky opens with a heartwarming update about her daughter’s upcoming birthday and their summer beach plans, before diving into how her own childhood eating patterns reflect her genetic makeup.
🧬 The Genetic Blueprint of Eating
The role of somatotypes (ectomorph, mesomorph, endomorph) in body composition and tendencies toward weight gain or leanness
Understanding the genetically predetermined “set point” for weight
Personal examples comparing her own adolescent stats with her daughter’s
🧠 Satiety and the MC4R Gene
Deep dive into the MC4R gene, a key regulator of satiety
How MC4R variants can affect appetite control and lead to overeating
A personal story from Olive Garden highlights how genetic predispositions show up in real life
🧪 Emotional Eating & the ANKK1 Gene
Introduction to the ANKK1 gene, which affects dopamine response and can drive emotional eating
The compounding effects of having multiple genetic variants (like MC4R + ANKK1)
🍽️ Practical Strategies to Support Satiety
Protein-first approach when dining out
High-protein snacks in the evening to prevent overeating
Focus on fiber and hydration to improve satiety
Smart use of supplements: omega-3s, vitamin D, fiber, and magnesium
Tips for volume eating and managing cravings based on texture
⏰ Fasting and Your Genes
How some individuals are genetically wired to skip breakfast
Dr. Novitsky shares her personal take on fasting and why it works for her
Your genetics can play a major role in how you feel hunger, how your body responds to food, and your susceptibility to emotional eating. The more you understand your unique genetic makeup, the more effectively you can design a lifestyle that supports your optimal health — without frustration or blame.
Dr. Novitsky is now enrolling participants in her Genetics Program – a unique opportunity to:
✅ Get a genetics testing kit
✅ Receive tailored supplement recommendations
✅ Build a comprehensive health plan based on your DNA
🔗 Enroll now at thefitcollective.com/genetics
Listen to Episode 264 Here
Or listen on your favorite podcast app: Apple Podcasts | Spotify | Android | YouTube
Chapters
00:00 – Personal Updates & Intro
03:22 – MC4R Gene & Satiety
10:07 – Satiety Strategies
18:08 – Eating Out Tips
22:00 – Supplements That Help
27:01 – Fasting & Genetics
30:13 – Wrapping Up + Program Info
Resources:
The Beginner Strength Training Program - 12 months for only $199! Enroll TODAY.
The Total Fitness Program combines Core & Floor, Muscles & Mindset, Advanced Strength Training, Yoga, and Meditation to give you the ultimate mind and body fitness experience over 12 months. Enroll HERE.
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*Ali Novitsky MD, this podcast, and podcast write-up are NOT providing medical advice. We do not recommend you start any exercise program without first consulting with your doctor!*
